Working with solitary-molecule optical and AFM imaging and power-spectroscopy strategies, we seek to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation passions consist of:
1996, initial mesoscopic demand density waves gadgets; and 1st electrical measurements on only one metal nanocluster amongst nanoelectrodes
Multicolor imaging of your bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and first at any time research of your dynamics DNA supercoils and the discovery of supercoil hopping
Experimental phase diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
You are a Christian. If you could make this kind of synthetic mobile, would you be a single step nearer to God, or would the function of God have diminished to some degree once again?
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Being familiar with fundamental procedures regulating the spatial and dynamic organisation of the DNA in live cells.
Right now, we also recognized that it should be achievable to utilize an individual semiconducting carbon nanotube to produce a transistor — and we established out to make it. We stretched personal cees dekker semiconducting nanotubes across metallic electrodes and utilized the underlying silicon substrate as a gate electrode, creating The essential 3-terminal format of a industry-outcome transistor (Fig.
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Later on we spoke again briefly since Dekker felt that our dialogue of his religion immediately became purely philosophical, whereas Furthermore, it concretely allows him in his function.
Visualization of unstained DNA nanostructures with State-of-the-art in-aim transmission electron microscopy methods
Strong-state nanopores have verified for being a incredibly functional probe for solitary-molecule Investigation of DNA. I will describe several of our modern results – exclusively DNA knots – and also our initiatives to grow the capabilities of sound-state nanopores even additional, within the path of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.